Spotlight on Hot Target Combos: PD-(L)1 & VEGF Accelerate Drug Development

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Spotlight on Hot Target Combos: PD-(L)1 & VEGF Accelerate Drug Development

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ACRObiosystems Co.Ltd.

2025 年 1 月 16 日

ACRObiosystems Co.Ltd.

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Bispecific antibodies (BsAb) are revolutionizing cancer treatment by targeting multiple pathways. PD-(L)1×VEGF BsAbs show promising antitumor effects by inhibiting immune escape and angiogenesis, offering new hope to cancer patients while accelerating biomedical innovations.

Dual Mechanism of Action

· Inhibiting PD-(L)1 Pathway

PD-(L)1×VEGF BsAb restore T-cell antitumor activity by disrupting the PD-L1/PD-1 interaction, enhancing immune response.

· Inhibiting VEGF Pathway

VEGF, a vital factor in tumor angiogenesis, promotes tumor growth by stimulating endothelial cell proliferation. By blocking VEGF-VEGFR interaction, these BsAbs inhibit angiogenesis, slowing tumor progression.

We have developed a variety of VEGF and PD-(L)1 family proteins, covering different species, subtypes, and tags, to accelerate PD-(L)1×VEGF BsAb drug development process.

Related Molecules

VEGF165	VEGF121	VEGF120	VEGF110
VEGF164	VEGF-B	VEGF-C	VEGF-D
VEGF R1	VEGF R2	VEGF R3	PD-(L)1

Verification Data

ELISA: High bioactivity confirmed.

Immobilized Human VEGF R1&VEGF R2, Fc Tag at 2 μg/mL (100 μL/well) can bind Human VEGF165, His Tag (Cat. No. VE5-H5248) with a linear range of 0.004-0.063 μg/mL (QC tested).

Request for Protocol

Immobilized Human VEGF121, His Tag (Cat. No. VE1-H5246) at 1 μg/mL (100 μL/well) can bind Human VEGFR1/R2, Fc Tag with a linear range of 0.4-6 ng/mL (QC tested).

Request for Protocol

SPR&BLI: Affinity verified.

Human VEGF R1 Protein, Fc Tag (Cat. No. VE1-H5253) captured on Protein A Chip can bind Human VEGF-B, His Tag (Cat. No. VE6-H5225) with an affinity constant of 0.52 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Request for Protocol

Loaded Biotinylated Human VEGF R1, His,Avitag (Cat. No. VE1-H82E3) on SA Biosensor, can bind Human VEGF165, His Tag (Cat. No. VE5-H5248) with an affinity constant of 0.236 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

Request for Protocol